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Using Cenforce 100 (which contains sildenafil citrate) with other medications can be risky if not properly managed. It should not be combined with nitrates (used for chest pain) or alpha-blockers (for high blood pressure or prostate issues), as this can cause a dangerous drop in blood pressure. Also, caution is needed with antifungals, antibiotics, HIV medications, and certain heart or liver drugs, which may interact with sildenafil, increasing side effects or reducing its effectiveness. Always consult a healthcare provider before combining Cenforce 100 with other prescriptions, supplements, or over-the-counter drugs.